WHAT IS THE DISTRIBUTION OF SARS-Cov-2 VARIANTS IN TURKEY?

Identifying mutations in SARS-CoV-2, especially functional variants, and their distributions in the population, is crucial to successfully inoculate individuals against COVID-19, as well as to identify and treat new cases. Therefore, Doğa Eskier, Dr. Gökhan Karakülah and Dr. Yavuz Oktay from IBG sought to identify the distribution and variances of three major SARS-CoV-2 variants (B.1.1.7,

A comprehensive look at the amino acid substitutions of SARS-CoV-2 isolates in Turkey

We estimated the full impact of the mutatome of 17 SARS-CoV-2 genomes isolated in Turkey, obtained from GISAID, on the tertiary structures of the coronavirus proteins. To this end, we employed multiple sequence alignment to identify changes in the amino acid sequences of 10 SARS-CoV-2 proteins, except surface glycoprotein, which we investigated in our previous

Identifying the mutatome of SARS-CoV-2 isolates in Turkey and its potential impact on surface glycoprotein structure

Mutations in the genome of a virus can complicate attempts to combat viral diseases, whether by causing a higher number of false negatives in diagnosis methods, such as by PCR, or attenuating or eliminating the effects of anti-viral medication or vaccination by disrupting the pharmacokinetic interactions of viral proteins with administered substances or preventing antibodies