To grant access to curated, comprehensive, and up-to-date information regarding SARS-CoV-2 isolates sequenced in Turkey and their mutatome to national and international researchers, in order to facilitate their efforts in fighting the continuing COVID-19 outbreak, IBG is proud to present an interactive map of the provinces of Turkey, which shows the number of isolates sequenced
Multiple sequence alignment (MSA), whether peptide or nucleotide, can be stored in multiple formats, most commonly Clustal’s .aln format or the FASTA format. While these files are plain text files, and can be opened and edited in any text editor, performing many of the tasks common to MSA analysis in such editors is unintuitive and
We estimated the full impact of the mutatome of 17 SARS-CoV-2 genomes isolated in Turkey, obtained from GISAID, on the tertiary structures of the coronavirus proteins. To this end, we employed multiple sequence alignment to identify changes in the amino acid sequences of 10 SARS-CoV-2 proteins, except surface glycoprotein, which we investigated in our previous
We have compared the genomes of 17 SARS-CoV-2 isolates in Turkey that have been sequenced to the reference genome sequence using multiple sequence alignment methods in order to identify any major structural variations. Our results are as follows: * 12 isolates have a 265-nucleotide long deletion on the 5’ end of the genome. No other
Mutations in the genome of a virus can complicate attempts to combat viral diseases, whether by causing a higher number of false negatives in diagnosis methods, such as by PCR, or attenuating or eliminating the effects of anti-viral medication or vaccination by disrupting the pharmacokinetic interactions of viral proteins with administered substances or preventing antibodies